Preliminary Programme

• Sunday
• Monday
• Tuesday
• Wednesday
• Posters

• Sunday, 9 October
  9:00-18:00	Registration

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  10:00-12:00	SHVM Satellite Meeting Sanofi Symposium on Diabetes and Cardiovascular Metabolism [Main conference room]
  10:00-10:10	Alex Zhang (Head of China R&D, Sonafi) Opening remarks
  10:50-11:10	Shengcai Lin (Xiamen University) Sensing metabolic stress and reprogramming of metabolic pathways
  10:50-11:10	Ashley Cowart (Medical University of South Carolina) Diverse roles for ceramide metabolism in cardiomyocyte lipotoxicity
  11:10-11:30	Haipeng Sun (Shanghai Jiaotong University) Branched chain amino acids in cardiac and metabolic diseases
  11:30-11:50	Yulan Wang (Chinese Academy of Sciences) Metabolomics techniques aiming for precision medicine
  12:00	Box lunch for attendees and discussions

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  9:30-12:00	Pre-Meeting Trainee Workshops [Room Lake View B(C)]
  9:30-10:40	Workshop 1 • In vivo MRI and MRS techniques for cardiac functional and metabolic studies in rodents
  	Desiree Abdurrachim (Eindhoven University of Technology) Michael Dodd (University of Oxford)
  10:50-12:00	Workshop 2 • Measurement of metabolic fluxes in the ex vivo working mouse heart
  	Matthieu Ruiz (Montreal Heart Institute) Maria da Luz Sousa Fialho (University of Oxford) Christoph Koentges (Heart Center Freiburg University)

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  Opening Session [Science Lecture Hall]
  13:00-13:30	Welcome Address and Preliminary Remarks Rui-Ping Xiao, E. Dale Abel, Christine Des Rosiers
  13:30-14:30	Keynote Plenary Lecture 1 Chair: Dale Abel Mark Anderson (Johns Hopkins University) New insights into the role of CaMKII in diabetic heart disease
  Session 1 – Insulin and IGF-1 Signaling in the Heart   [Science Lecture Hall] Chairs: Heiko Bugger and Miranda Nabben
  14:30-15:00	Yang Kevin Xiang (UC Davis) Inhibiting insulin-mediated β2AR activation prevents diabetes-associated cardiac dysfunction
  15:00-15:30	Walter Koch (Temple University) Novel role for GRK2 in cardiac function and metabolism
  15:30-16:00	Coffee Break
  16:00-16:30	Jaetaek Kim (Chung-Ang University) IGF-1 signaling and cardiac senescence
  	Short talks selected from submitted abstracts
  16:30-16:45	Michael Dodd (Oxford, UK) Fatty acids impair HIF1α activation and suppress metabolic adaptation to hypoxia in insulin resistance
  16:45-17:00	Xinli Hu (Beijing, China) The role of MG53 in the development of diabetic cardiomyopathy
  17:00-17:15	Joost Luiken (Maastricht, Netherlands) Vacuolar H+-ATPase (v-ATPase) as a lipid and glucose sensor in the heart
  17:15-17:30	Quan-Jiang Zhang (Iowa City, IA, USA) mTOR–independent regulation of starvation-induced autophagy in cardiomyocytes by Akt1
  17:30-19:30	Reception and Poster Session 1 [Room Lake View A(D)]
  19:00	Dinner     [Time Western Restaurant]

• Monday, 10 October
  Session 2 – Novel Metabolic Signaling Pathways in the Heart [Science Lecture Hall] Chairs: Michael Sack and Florin Despa
  8:30-9:00	Brian Wong (KU Leuven) Angiogenesis revisited: role and (therapeutic) implications of endothelial metabolism
  9:00-9:30	Chan Bae Park (Ajou University School of Medicine) Lactate dehydrogenase deficiency cause cardiomyopathy
  9:30-10:00	Rui-Ping Xiao (Peking University) MG53 and diabetic cardiomyopathy
  10:00-10:30	Christine Des Rosiers (University of Montreal) Protecting the diabetic heart through modulation of lipid metabolism and cell signaling: insights from dietary and transgenic mouse models
  10:30-11:00	Coffee Break
  11:00-11:30	Pingsheng Liu (Chinese Academy of Sciences) Lipid droplet proteins and metabolic diseases
  	Short talks selected from submitted abstracts
  11:30-11:45	Heiko Bugger (Freiburg, Germany) Adiponectin receptor agonism improves cardiac function in diabetic db/db mice
  11:45-12:00	Chad Grueter (Iowa City, IA, USA) Med1 is necessary for cardiac transcriptional regulation of oxidative metabolism
  12:00-12:15	Lisa Heather (Oxford, UK) Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart
  12:15-12:30	Ni-Huiping Son (New York, NY, USA) Endothelial CD36 is the gatekeeper of parenchymal cell intermediary metabolism
  12:30-14:30	Lunch and Poster Session 2     [Room Lake View A(D)]
  Session 3 – The "William C. Stanley" Early Investigator Awards [Science Lecture Hall] Chairs: Christine Des Rosiers and Xiao-Wei Chen
  14:30-14:45	Trevor Fidler (Iowa City, IA, USA) Glucose metabolism is essential for platelet function
  14:45-15:00	Qi Ma (Beijing, China) A novel PIP3-binding protein mediates mitochondrion-centered AKT signaling for platelet survival
  15:00-15:15	Graham McGinnis (Birmingham, AL, USA) Time-of-day and cardiomyocyte circadian clock dependent regulation of myocardial autophagy
  15:15-15:30	Amos Erfei Song (Toronto, ON, Canada) Lipocalin-2 promotes cardiac dysfunction via HMGB1-induced TLR4 signaling and NLRP3 inflammasome activation
  Session 4 – Novel Mediators of Diabetes-Associated Cardiac Pathology [Science Lecture Hall] Chairs: Jan Glatz and Michael Dodd
  15:30-16:00	Florin Despa (University of Kentucky) Amylin and diabetic cardiomyopathy
  16:00-16:30	Gangjian Qin (Northwestern University) Diabetes and EPC dysfunction
  16:30-17:00	Coffee Break
  17:00-17:30	Anne Hafstad (Tromsø University) NADPH oxidases in diabetic cardiomyopathy
  	Short talks selected from submitted abstracts
  17:30-17:45	Hyun Kook (Gwangju, South Korea) Roles of nuclear receptors in cardiac hypertrophy: implications of estrogen-related receptor gamma, small heterodimer partner, and vitamin D3 receptor
  17:45-18:00	Ajay Shah (London, UK) Nox4-dependent metabolic reprogramming facilitates cardiac adaptation to chronic pressure overload
  18:00-19:30	Reception and Poster Session 3 [Room Lake View A(D)]
  19:00	Dinner     [Time Western Restaurant]

• Tuesday, 11 October
  8:00-9:00	Keynote Plenary Lecture 2 [Science Lecture Hall] Chair: Ruiping Xiao Donald Bers (UC Davis) Calmodulin and CaMKII signaling in cardiac myocytes
  Session 5 – Mitochondria and Oxidative Stress Novel Insights [Science Lecture Hall] Chair: Ellen Aasum
  9:00-9:30	Heping (Peace) Cheng (Peking University) Mitoflash in diabetes
  9:30-10:00	Wang Wang (University of Washington) Mitochondrial dynamics in the stressed heart
  10:00-10:30	Fabio Di Lisa (University of Padua) Monoamine oxidase and mitochondrial ROS formation in diabetic cardiomyopathy
  10:30-11:00	Coffee Break
  11:00-11:30	Rebecca Ritchie (Baker IDI, Australia) Targeting oxidative stress to limit diabetic cardiomyopathy
  11:30-12:00	Jeanine Prompers (Eindhoven University) Evaluation of mitochondrial function by non-invasive MR Spectroscopy
  	Short talk selected from submitted abstracts
  12:00-12:15	Matthieu Ruiz (Montreal, QC, Canada) Dissecting the impact of MK2 deletion on lipid metabolism in a mouse model of diabetes through lipidomics
  12:15-13:15	Lunch
  13:30-18:00	Excursion to the Summer Palace Please see details in the Information page (Social Events)
  18:30	Banquet     [Elites Banquet Hall]

• Wednesday, 12 October
  8:00-9:00	"William C. Stanley" Keynote Lecture [Science Lecture Hall] Chair: Christine Des Rosiers E. Dale Abel (University of Iowa) Insulin, autophagy and mitochondrial metabolism
  Session 6 – Mitophagy and Autophagy [Science Lecture Hall] Chairs: Terje Larsen and Ashley Coward
  9:00-9:30	Qiangrong Liang (NY Institute of Technology) Mitophagy and diabetic heart
  9:30-10:00	Lea Delbridge (University of Melbourne) Cardiac energy stress and glycophagy response
  10:00-10:30	Bao-Liang Song (Wuhan University) A way of LDL-cholesterol out of lysosome through membrane contacts
  10:30-11:00	Coffee Break
  	Short talks selected from submitted abstracts
  11:00-11:15	Kathleen MacLeod (Vancouver, BC, Canada) Heterozygous deletion of ROCK2 prevents mitochondrial fission through indirect modulation of Drp1 phosphorylation in hearts from mice with diet-induced obesity
  11:15-11:30	Michael Sack (Bethesda, MD, USA) Fasting regulates NLRP3 inflammasome activation in humans by modulating mitochondrial integrity
  11:30-11:45	Xing Zhang (Xi'an, China) Enhanced myocardial fatty acid metabolism protects the pressure-overload heart against heart failure through restoration of mitochondria dynamics
  11:45-12:00	Meeting summary and introduction of 2017 meeting [Science Lecture Hall]
  12:00-13:00	Box lunch
  13:00-18:00	Departure or Optional Excursions Optional excursions (not included in the registration fee) are available this afternoon and on Thursday, 13 October; please see the Information page (Social Events)

• Posters

  When preparing your poster, please remember that its maximum size is 90 x 120 cm (width x height). Note that the orientation is portrait, not landscape.

  Correct format...    Wrong format...

  The exact distribution of posters in the different sessions is indicated below.

  Independently of the session to which you have been assigned, you are kindly invited to put up your poster in time for the first poster session, scheduled for Sunday, 9 October, at 17:30. All posters should stay up for the entire duration of the meeting. Poster presenters are required to be available for discussion during their assigned session.

  • Session 1
  • Session 2
  • Session 3

  • Poster Session 1

    Sunday, 9 October • 17:30-19:30

    P1.1 · Ellen Aasum (Tromsø, Norway)
    Exercise-induced ischemic cardioprotection in obese mice was not abrogated by an acute fat-load

    P1.2 · Xiao-Wei Chen (Beijing, China)
    Quantitative Control of VLDL Lipid Transport by the CMRD Gene SAR1B

    P1.3 · Florin Despa (Lexington, KY, USA)
    Ryanodine receptor hyperphosphorylation induces arrhythmias in type-2 diabetes

    P1.4 · Andrew S. Fenning (North Rockhampton, QLD, Australia)
    Perindopril improves cardiovascular function in a middle- aged diet-induced rat model of the metabolic syndrome

    P1.5 · Ilvy M.E. Geraets (Maastricht, Netherlands)
    Metabolic characterization of stem cell-derived cardiomyocytes: insulin resistance in a dish

    P1.6 · SongMi Han (Suwon, South Korea)
    Lactate dehydrogenase deficiency cause cardiomyopathy

    P1.7 · Raffaella Isola (Monserrato, CA, Italy)
    Cardiac mitochondria of female diabetic rats are poorly affected by diabetes

    P1.8 · Christoph Koentges (Freiburg, Germany)
    Tissue-specific regulation of mitochondrial OXPHOS abundance in mice lacking AdipoR1

    P1.9 · Hyun Kook (Gwangju, South Korea)
    Roles of nuclear receptors in cardiac hypertrophy: implications of estrogen-related receptor gamma, small heterodimer partner, and vitamin D3 receptor

    P1.10 · Joost Luiken (Maastricht, Netherlands)
    Vacuolar H⁺-ATPase (v-ATPase) as a lipid and glucose sensor in the heart

    P1.11 · Emmy Manders (Eindhoven, Netherlands)
    High-fat diet feeding in mice may partially protect the heart from pressure overload-induced heart failure - a longitudinal study of cardiac metabolism and function

    P1.12 · Rianne Nederlof (Düsseldorf, Germany)
    Insulin-like growth factor 1 treatment preserves cardiac function after myocardial infarction independent of insulin-like growth factor 1 receptor in cardiomyocytes

    P1.13 · Jian-Fei Pei (Beijing, China)
    Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice

    P1.14 · Andrea Schrepper (Jena, Germany)
    Metformin averts high fat diet-induced insulin resistance and protects mitochondrial function

    P1.15 · Amos Erfei Song (Toronto, ON, Canada)
    Lipocalin-2 promotes cardiac dysfunction via HMGB1-induced TLR4 signaling and NLRP3 inflammasome activation 

    P1.16 · Haipeng Sun (Shanghai, China)
    Branched-chain amino acids and cardiaometabolic diseases

    P1.17 · Romina Vargiu (Monserrato, CA, Italy)
    Does early stage diabetes induce an adaptation of contractile machinery in female rats?

    P1.18 · Christina Werner (Jena, Germany)
    Low genetically determined exercise capacity protects cardiac and mitochondrial function during pressure overload

    P1.19 · Constantin Witt (Freiburg, Germany)
    Differential susceptibility to pressure overload-induced cardiac dysfunction
    in 129S1/J and C57BL/6J mice

    P1.20 · Coert J. Zuurbier (Amsterdam, Netherlands)
    The kidney-targeted novel diabetes agent empagliflozin has direct cardiac effects

  • Poster Session 2

    Monday, 10 October • 12:30-14:30

    P2.1 · Yin Cai (Hong Kong, China)
    COX-2 inhibition protects against hypoxia/reoxygenation-induced cardiomyocyte apoptosis via Akt-dependent enhancentment of iNOS expression

    P2.2 · Youn Wook Chung (Seoul, South Korea)
    Targeted disruption of PDE3B moderates atherosclerosis by reduction of inflammation in adipose tissue, not in macrophages

    P2.3 · Michael S. Dodd (Oxford, United Kingdom)
    Fatty acids impair HIF1α activation and suppress metabolic adaptation to hypoxia in insulin resistance

    P2.4 · Trevor P. Fidler (Iowa City, IA, USA)
    Glucose metabolism is essential for platelet function

    P2.5 · Jan F.C. Glatz (Maastricht, Netherlands)
    Propionic acidemia as a cause of adult-onset dilated cardiomyopathy

    P2.6 · Lisa C. Heather (Oxford, United Kingdom)
    Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart

    P2.7 · Kirsten M. Jansen (Tromsø, Norway)
    Glucagon-like peptide 1 (GLP-1) prevents peripheral insulin resistance induced by surgical trauma

    P2.8 · Hyun Kook (Gwangju, South Korea)
    MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

    P2.9 · Terje S. Larsen (Tromsø, Norway)
    Absorption of essential fatty acids in wax-ester rich oil from the marine crustacean, Calanus finmarchicus, in healthy men and women

    P2.10 · Qi Ma (Beijing, China)
    A novel PIP3-binding protein mediates mitochondrion-centered AKT signaling for platelet survival

    P2.11 · Graham R. McGinnis (Birmingham, AL, USA)
    Time-of-day and cardiomyocyte circadian clock dependent regulation of myocardial autophagy

    P2.12 · Yeon Hee Noh (Busan, South Korea)
    Necrox-5 regulates mitochondria biogenesis and inflammation response in ischemic rat heart

    P2.13 · Yifu Qiu (Beijing, China)
    Innate immune orchestration of brown and beige fat thermogenesis

    P2.14 · Michael Schwarzer (Jena, Germany)
    Genetic predisposition for exercise capacity and exercise training affects recovery of cardiac function after ischemia

    P2.15 · Min Ho Song (Gwangju, South Korea)
    Matricellular protein CCN5 reverses established cardiac fibrosis and prevents atrial fibrillation

    P2.16 · Xiaoqiang Tang (Beijing, China)
    The metabolic sensor SIRT1 regulates the cardiac transcription factor Nkx2.5

    P2.17 · Yan Wang (Wuhan, China)
    A new ANGPTL protein that directs triglyceride partitioning with ANGPTL3

    P2.18 · Monte S. Willis (Chapel Hill, NC, USA)
    Circadian regulation of the myocyte-specific ubiquitin ligase MuRF1is dependent upon CLOCK and BMAL1 in vivo

    P2.19 · Wenjuan Xing (Xi'an, China)
    Vasonatrin peptide inhibits endoplasmic reticulum stress and attenuates myocardial ischemia/reperfusion injury in diabetic rats

  • Poster Session 3

    Monday, 10 October • 18:00-19:30

    P3.1 · Ting Cao (Suzhou, China)
    Over-expression of mitochondria-targeted calpain-1 induces dilated heart failure in transgenic mice: an important role of mitochondrial reactive oxygen species

    P3.2 · L. Ashley Cowart (Charleston, SC, USA)
    Diverse roles of ceramide synthase isoforms in diabetic cardiomyopathy

    P3.3 · Stavros G. Drakos (Salt Lake City, UT, USA)
    Evidence of glycolysis upregulation and pyruvate mitochondrial oxidation mismatch during mechanical unloading of the failing human heart: implications for cardiac reloading and conditioning

    P3.4 · Feng Fu (Xi'an, China)
    Direct evidence that myocardial insulin resistance following myocardial ischemia contributes to post-ischemic heart failure

    P3.5 · Chad E. Grueter (Iowa City, IA, USA)
    Med1 is necessary for cardiac transcriptional regulation of oxidative metabolism

    P3.6 · Maximilian E. Hölscher (Freiburg, Germany)
    Sustained cardiac efficiency in female diabetic mice despite increased fatty acid utilization

    P3.7 · Hyoung Kyu Kim (Busan, South Korea)
    Tetrahydrobiopterin supplementation enhances mitochondria and cardiac function in diabetic rat model via via activation of Akt and PGC1-α signaling pathway

    P3.8 · Hyun Kook (Gwangju, South Korea)
    Protein phosphatase PP2A regulates hypertrophic responses by dephosphorylation of histone deacetylase 2 in the heart

    P3.9 · Wang-Soo Lee (Seoul, South Korea)
    Insulin/IGF-1 receptor signaling is essential for sinus node function

    P3.10 · Kathleen M. MacLeod (Vancouver, BC, Canada)
    Heterozygous deletion of ROCK2 prevents mitochondrial fission through indirect modulation of Drp1 phosphorylation in hearts from mice with diet-induced obesity

    P3.11 · Rianne Nederlof (Düsseldorf, Germany)
    Acute detachment of hexokinase II from mitochondria increases oxygen consumption of the intact mouse heart

    P3.12 · Faisal Nuhu (Hull, United Kingdom)
    Correction of anaemia ameliorates oxidative stress in uraemic cardiomyopathy

    P3.13 · Matthieu Ruiz (Montreal, QC, Canada)
    Dissecting the impact of MK2 deletion on lipid metabolism in a mouse model of diabetes through lipidomics

    P3.14 · Ni-Huiping Son (New York, NY, USA)
    Endothelial CD36 is the gatekeeper of parenchymal cell intermediary metabolism

    P3.15 · Maria da Luz Sousa Fialho (Oxford, United Kingdom)
    HIF activator DMOG improves functional recovery following ischaemia-reperfusion in the type 2 diabetic heart

    P3.16 · Anne Van Steenbergen (Brussels, Belgium)
    SMIT1 mediates the production of reactive oxygen species induced by hyperglycemia in the heart

    P3.17 · Adam R. Wende (Birmingham, AL, USA)
    Epigenetic signatures of human diabetic and ischemic heart failure

    P3.18 · Monte S. Willis (Chapel Hill, NC, USA)
    Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

    P3.19 · Quan-Jiang Zhang (Iowa City, IA, USA)
    mTOR–independent regulation of starvation-induced autophagy in cardiomyocytes by Akt1